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Tramadol vs Oxycodone For Pain Relief: Comparison

Tramadol vs Oxycodone

Nowadays, many individuals are suffering from the pain-related condition. Patients with pain condition may have various reasons, such as muscle strains, broken bones, dental illness, post-operative surgery, childbirth, infections, and burns. etc. Tramadol and oxycodone are two medicines used to treat this health condition. Today we are discussing Tramadol vs oxycodone differences.

Tramadol drug helps patients who are suffering from pain-related problems, as it may help reduce the pain effects. Oxycodone medicine is also helpful to give better results and help to relieve the severity of pain.

So, let’s understand the comparison between two pain medications Tramadol and Oxycodone.

Comparison: Tramadol vs Oxycodone Drug

Here we are discussing various factors for which both are may differ from each other.

What is Tramadol Drug?

Tramadol is a generic variant and belongs to the narcotic analgesics drug class. This medicine is used to get relief from severe ongoing pain conditions. It is categorized as a Schedule IV Controlled Substances Act. It can lead to addiction or habit-forming in patients.

What is Oxycodone?

Oxycodone is a generic drug that also falls under the category of opioid analgesics. This drug belongs to Schedule II Controlled Substance category. It is used to treat several pain problems.

This generic drug contains Oxycodone hydrochloride in the form of an active chemical component. Oxycodone is an FDA-approved prescription-only drug for treating the effects of pain.

Function: Tramadol vs Oxycodone

Tramadol medicine works in the brain and spine to treat pain. It has a low potential of being addictive.

Oxycodone medicine can attract three opioid receptors such as mu receptor, kappa and delta-receptors in the nervous system of the brain. It blocks the pain nerve signals to get transmitted between the brain and the body.


  • Tramadol’s medicine effects for up to 5 to 6 hours in the body. O-desmethyl-tramadol has a moderately longer half-life of 8 hours.
  • The half-life span of Oxycodone is 3 hours.

Dosage Strength and Forms:

1) Tramadol comes in several dosage forms such as an oral tablet, solution, capsule, suspension, extended-release (ER) capsule 24 hours and ER tablet. It has various dosage strengths that include-

2) Oxycodone is available in the form of immediate-release and extended-release tablets for treating chronic pains.

Dosage Information:

  • Patients can take The tablets and solution of Tramadol regularly every 4 to 6 hours with or without a meal.
  • The immediate release dosage of Oxycodone drug can be regularly every 4 to 6 hours with or without a meal. The doctor prescribes the extended-release dosages of this drug take with meals every 12 hours per day.

Uses: Oxycodone vs Tramadol

Tramadol is used to treat and relieve mild to severe pain. It acts in the Central Nervous System of the brain and spinal cord to reduce the amount of pain.

Oxycodone drug is used in the treatment of moderate to severe pain conditions in people. It may cause due to various reasons such as injuries, accidents, etc. But, it is also used for several off-label purposes which can be treated using this medicine like neuropathic pain or tissue damage pain.

Side Effects of Both Drugs:

Both drugs have potential side effects, which are as follows-

  • Noisy breathing
  • Sighing
  • Shallow breathing
  • Breathing that stops during sleep
  • Slow heart rate
  • Feeling light-headed
  • Convulsions (seizures)
  • Weak pulse
  • Nausea
  • Vomiting
  • Loss of appetite
  • Dizziness
  • Worsening tiredness
  • Agitation
  • Hallucinations
  • Fever
  • Sweating
  • Shivering
  • Fast heart rate
  • Muscle stiffness
  • Twitching
  • Loss of coordination
  • Diarrhea
  • Confusion
  • Unusual thoughts
  • Cold
  • Clammy skin

Precautions for Both Tramadol and Oxycodone:

  • Do not share the dosage of these drugs with other patients who are suffering from pain conditions as it is a prescription-only medicine.
  • If anyone has taken an overdose they react with serious side effects such as muscle weakness, unable to respond or wake up, black circles around the eyes, extreme drowsiness or sleepiness etc.
  • Before taking these medications, one must tell a doctor if they have any other allergies.
  • Both medications may make feel dizzy and drowsy.
  • Do not take these drugs if one drinks alcohol as these can cause severe side effects or even death.
  • If people take Tramadol and Oxycodone medicines, they should avoid driving or other activity.
  • People never use this drug, who has asthma or breathing problems.
  • Do not use Tramadol and Oxycodone medicines during pregnancy. Because they may cause harmful symptoms in the newborn baby.


In conclusion, Tramadol and Oxycodone are two medications used for treating various pain in individuals. They work in different processes in the people’s body to treat pain.

People may face both advantages and disadvantages after taking these drugs. So, it will be helpful for people to follow the precautions during these drug courses.

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