Taking unhealthy beverages and foods regularly may lead to adverse health problems. The reason is that they contain maximum levels of fats, sodium, sugar and many more. According to a study by CDC (Centers for Disease Control and Prevention), it was observed that 42.4% of the population who are in their 20s or older are gaining weight and nearly 73.6% of them are experiencing extreme weight gain (obesity).
Moreover, not only foods and drinks are affecting their lives, genetics, disturbed sleep routine, lack of physical activity, medical conditions, sedentary behaviors such as watching TV and smartphone, environmental conditions etc., may also lead to weight in them. All these issues influence diseases like high cholesterol, type 2 diabetes, heart stroke and others.
In spite of these challenges, doctors may advise you on many methods to lose your weight. For instance, developing eating habits and exercise. But, they may also prescribe you Contrave and Phentermine drugs for weight loss.
In today’s blog, we will understand the key comparison between Contrave vs Phentermine with factors like uses, mechanism of the drug, side effects and precautions.
Difference Between Contrave And Phentermine
Overview
Contrave
Contrave is a mixed combination of both bupropion and naltrexone. Bupropion is an antidepressant medicine that can also decline appetite. Naltrexone is usually given to block the effects of opioids drugs or alcohol in people with addiction problems. Naltrexone may also be used to limit or control hunger and food cravings.
This drug works as an appetite suppressant, and it reduces cravings.It is a prescribed medicine for weight loss which can be obtained only in branded versions.Takeda Pharmaceuticals is the manufacturing company of this in the USA.
Phentermine
Phentermine pills is used for short-term treatment of weight gain in individuals. The FDA had approved this medicine for patients to lose weight. This medication is a stimulant and comes under anorexiants drugs to lower appetite and enhance energy level.
This medicine has a high potential for abuse and dependence, and is categorized as Schedule IV controlled substance. It can be obtained in both generic and branded formulations. Adipex-P, Lomaira and Ionamin are a few of the branded forms of this drug. The manufacturing company of Phentermine is KYK Tech in the US.
Mechanism of Action
So, here are functions of Contrave vs Phentermine
Contrave
Contrave is a distinct weight-loss medication that combines two different medications: naltrexone and bupropion. Each of these ingredients is available on its own for different purposes.
Naltrexone is an opioid blocker (antagonist). It blocks the rewarding effects of substances such as opioids and alcohol. And it’s used to treat substance use disorders. Bupropion is an antidepressant. It raises the levels of chemicals in the brain (dopamine and norepinephrine) to improve mood and help you quit smoking and other opioids drugs.
Phentermine
Phentermine is a central nervous stimulant that may be used to treat obesity. Phentermine belongs to the class of drugs known as anorectics or anorexigenics. This drug works by modulating the activity and level of serotonin, dopamine and acetylcholine that leads to anorectic effects. In addition, it enhances the activity of beta-2 adrenergic receptors from presynaptic vesicles.
Uses
Contrave
This drug is effective for chronic weight management in people. It may help to lower the food intake and reduce weight in the patients with obesity or weight related issues. It works effectively with proper diet and exercise.
While consuming this drug, it is well-advised to avoid foods which contain high-fat and calories as it may increase more health complications.
Phentermine
Phentermine is used to treat a speedy weight loss in overweight people. It is used to work together with diet and exercise to treat obesity, especially in people with risk factors such as high blood pressure, high cholesterol, or diabetes.
Phentermine is similar to an amphetamine. It stimulates the central nervous system (nerves and brain), which increases your heart rate and high blood pressure and decreases your appetite to a very low point.
Dose and Dosage Strength
Contrave Dosage Strength
The available dosage strength of Contrave is in extended-release (ER) tablet form which are mentioned below:
Bupropion: 90 mg
Naltrexone: 8 mg
Doses
The initial dosage of this drug is 8 mg once in the morning. If the weight of the patient is 58 kg or less, the recommended dose is one tablet in the evening and morning. If the weight is 59 kg to 73 kg, then two pills in the morning and one in the evening. If more than 74 kg, two tablets in the morning and evening or as per advised by the doctor.
However, this medicine should be discontinued after consuming for 12 weeks, if the individual has not lost 5% of body weight. Talk about any concerns with your healthcare expert before taking the right amount of dosage.
Phentermine Dosage Strength
Phentermine is available in different strengths and forms.
Tablet: 8 mg, 37.5 mg
Capsule: 15 mg, 37.5 mg, 30 mg
Doses
The recommended dose of this drug is 8 mg, although it may vary as some of the healthcare experts may start a dose with higher strength. If any individual is suffering from mild to moderate kidney damage then the dosages may not require adjustment.
It is essential to follow the dosage instructions and inform the physician if facing any difficulty.
Side effects
Here are some side effects of Contrave vs Phentermine:
Common side effects of both the drugs are similar. They are as follows:
- Constipation
- Headache
- Diarrhea
- Dizziness
- Insomnia
- Vomiting
- Nausea
- Dry mouth
- Hair loss
- Rash
- Menstrual changes
- Acne
The serious side effects of Contrave include:
- Liver damage
- Seizures
- High blood pressure
Phentermine comes with adverse side effects. They are:
- Cardiovascular problems
- Euphoria
- Sexual changes
- Tremor
- Hives
- Restlessness
- Rapid heart rate
Precautions
Here are some major precautions while taking Contrave vs Phentermine
- These drugs may interact with other medicines like sedatives, antihistamines and antidepressants. Inform your physician before taking.
- Regularly monitor your blood pressure and glucose level, as these drugs may raise blood pressure and lower blood sugar.
- Pregnant and breastfeeding women should not consume these medicines.
- Phentermine may increase the risk of heart disease and nervous system, if interacted with alcohol.
- If you stop these drugs suddenly, it may cause withdrawal symptoms. For instance, anxiety, goosebumps, sweating, muscle twitching etc.
- Tell your healthcare advisor after overdosing as it may lead to side effects in people.
- Store these drugs in an air-tight container and keep away from heat.
- Do not break, chew or crush these tablets or capsules. Swallow it with a glass of water.
- Avoid operating machinery and driving after taking these drugs.
- Take recommendations for your exercise and diet from your doctor.
- Always follow dosage instructions provided by your physician in order to prevent side effects.