Pain is one of the major factors that everybody has or experiences because it can emanate from various processes like injury, inflammation process, arthritis, menstrual cramps, and so on. For the pain, doctors have some medicines which are given to the patients to relieve their pain. They are Diclofenac and Ibuprofen.
Diclofenac and ibuprofen are primarily used against fever, pain, and inflammation. Most of the people utilizing these drugs for concluding pain, marvel, and fever comprise Diclofenac and Ibuprofen both of which are apart from NSAIDs.
Diclofenac and Ibuprofen in the same manner share certain indications while more differences include general variations while some as-diclofenac Comparison with ibuprofen, some common and some different concerning therapeutic classification, therapeutic group, or structurally. Buffy’s body paper will be addressed and a comparison of ibuprofen with diclofenac in any aspect which covers their side effects, usage, site, mechanisms of action, and more.
DIFFERENCE BETWEEN DICLOFENAC AND IBUPROFEN DRUGS
Overview
Diclofenac
Diclofenac is a nonsteroidal anti-inflammatory drug. Grozny is NSAID expert unlike ibuprofen. The production of the drug is both a generic drug and a branded one. It is sold under Voltaren, Zipsor, and Dyloject brand names, but these may differ from one Country to another.
It alleviates menstrual pain, osteoarthritis, ankylosing spondylitis, arthritis, and other diseases in the patients. Also, it is used in the treatment of migraines.
In the United States, it is an approved drug by the Food and Drug Enforcement Administration but only on prescription. It is not controlled which means the medicine does not have tendencies of being abused or misused.
Ibuprofen
Ibuprofen is also classified as an NSAID. The medication is taken orally. This drug is bought and sold in both generic and brand-named forms. Martin and Advil are a few of the trade names under which the product is available.
Approval of this over-the-counter drug ibuprofen is provided in the USA g by the Food and Drug Enforcement Administration therefore making it available without prescription in minor doses This product does not present any difficulties regarding misuse and therefore is not defined as a controlled drug.
Mechanism of Drug Action
Diclofenac
Diclofenac works to inhibit two of the three cyclooxygenases; namely, COX-1 and COX-2. Cyclooxygenase is one of the enzymes responsible for the synthesis of prostaglandins, which is active during fever, pain, and inflammation, thus producing reactive inflammatory mediators.
Therefore, by reversibly inhibiting the activity of COX enzymes specifically COX2, the production of prostaglandin is reduced thus those effects being acute pain relief and decreasing inflammation of other tissues.
The bio half-life of any given dose of the medication Diclofenac is approximately 1.8 hours, with an elimination half-life of 2-6 hours.
Ibuprofen
Also in the case of Ibuprofen, it shall be noted that Ibuprofen also in a way inhibits the action of COX 1 and COX 2 enzymes and prevents arachidonic acid converting into prostaglandins, however, ibuprofen lacks the specificity of COX inhibition. Ibuprofen, once eliminated from the body, all the COX activity returns to its pre-treatment levels.
It lowers the levels of reacting and prostaglandins and other symptoms and pain therefore decreasing.
The bio half-life of the Ibuprofen drug is precise approx 4 to 6 hours.
Uses
Diclofenac
Pain relief medicine Diclofenac is used in the treatment of pain and inflammation in cases of osteoarthritis, rheumatoid arthritis, migraine, ankylosing spondylitis, etc.
It is also used for alleviating some other forms of acute pain such as a sprain, backache, strain, and so forth.
Ibuprofen
Harmful conditions such as muscle cramps, abortion, dental procedures, and headaches are some of the health factors from which Ibuprofen is made for alleviation. Painkillers like ibuprofen do not stop advancing viruses, and do more than just, relieve pain.
Though the most common indications for ibuprofen therapy are the treatment of fever and inflammation, these are not the only functions of the medication.
Dosage Strength
Diclofenac
Oral Tablet
IR (Immediate Release)
- 25 mg
- 50 mg
- 75 mg
XR (Extended Release)
- 100 mg
Oral Capsule
- 18 mg
- 25 mg
- 35 mg
Tropical (Gel)
- 1%
- 3%
Ibuprofen
Oral Capsule
- 200 mg
Tablets
- 100 mg
- 200 mg
- 400 mg
- 600 mg
- 800 mg
Suspension
- 100 mg/5 mL
- 50 mg/1.25 mL
Side Effects
Diclofenac
Here is a list of side effects you may experience while consuming diclofenac drug:
- Symptoms of flu
- Bruises
- Rapid weight gain
- Trouble breathing
- Nausea and vomiting
- Diarrhea
- Stomachache
- Pain while urinating
- Indigestion
- Sweating
- Itching
- Dizziness
- Drowsiness
- Constipation
- Pain and swelling in arms and leg
Ibuprofen
Side effects you may experience when consuming ibuprofen drug:
- Stomachache
- Nausea and vomiting
- Diarrhea
- Dizziness
- Skin rash and irritation
- Indigestion
- Headache
- Blood in urine
- Shortness of breath
- Weakness
- Chest pain
- Allergic reaction
- Blood in vomit
- Black stool
Precautions
The approval of diclofenac along with ibuprofen brought effective anti-inflammatory drugs into wider use. However, some precautions regarding the use of these drugs are warranted to limit the negative effects.
- Patients with a previous illness of CVD, hyperlipidemia, and/or hypertension core critical conditions must communicate to their doctor further details. The diclofenac drugs may increase the incidences of stroke and heart attack.
- Neither ibuprofen nor diclofenac should be used by patients suffering from diseases such as inflammatory bowel disease, ulcer, and gastritis because the drugs are likely to aggravate the conditions and cause more chances of gastric bleeding and ulcers.
- A clear prologue should first be endorsed before diclofenac and ibuprofen are administered to patients struggling with kidney and liver disease.
- Don’t consume alcohol while taking either of these tablets.
- Ibuprofen as well as diclofenac has its interaction with quite several drugs. All these drugs may be used but consultation with your healthcare givers is a requirement.
- These medicines must not be chewed, broken, or crushed.
- Ensure that all these drugs are kept away from children.
- Pregnant and breastfeeding women should contact a doctor before taking diclofenac or ibuprofen.
- If you encounter any side effects after consuming these drugs instantly seek medical advice.