Ibuprofen is nonsteroidal anti-inflammatory drug (NSAID), which is used to treat fever, inflammation, mild to moderate pain, rheumatoid arthritis, migraines and dysmenorrhea. It is FDA approved medicine that was patented in 1961. It is most widely taken oral medicine in the world & taken by teenagers and adults as 200-400 mg per dose in every 4-6 hours.
Drug Mechanism
The primary mechanism of ibuprofen is the non-selective and reversible suppress of the cyclooxygenase enzymes (COX), which is preferred for the synthesis of prostaglandins through the archidonic acid pathway. COX is required to convert arachidonic acid to prostaglandin H2(PGH2) in the body and then PGH2 converted in prostaglandin. The Inhibition of COX via ibuprofen lowers the level of prostaglandins which is made by the body.
There are two forms of cyclooxygenase (COX) enzymes in the body COX-1 and COX-2. COX-1 inhibit blocks the formation of thromboxane and COX-2 reduce pain and inflammation effects.
Forms and Dosage
Tablet
- 100mg
- 200mg
- 400mg (Rx)
- 600mg (Rx)
- 800mg (Rx)
Capsule
- 200mg
Tablet (chewable)
- 50mg
- 100mg
Oral suspension
- 100mg/5ml
- 40mg/ml
Drug Effectiveness
- Ibuprofen is effective to relief from mild to moderate pain and aches that is related to the headache, migraine, backache, and muscle aches.
- Its higher dose has also been shown effectiveness in decreasing inflammation.
- Ibuprofen is most effective and widely used medicine to relieve from fever.
- Ibuprofen is effective painkiller to control postoperative pain after third molar surgery.
- It is used to get relief from such conditions like arthritis, rheumatoid without any contradictions.
- Specific NSAIDs drug may be effective against breast cancer.